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SS-31 Elamipretide 25mg Pre Mixed

£221.94£660.82

SS-31 Elamipretide has the ability to penetrate cell and organelle membranes, and is thought to interfere with the production of reactive oxygen species within the mitochondria, subsequently improving physiological function. SS-31 binds selectively to cardiolipin, a phospholipid expressed exclusively on the inner mitochondrial membrane, and changes in cardiolipin have been associated with age and multiple diseases.

Pre Mixed Cartridge and Kit:
* 
1 x Cartridge (The cartridge is premixed with the peptide vial of your choice and Bacteriostatic Water)
* 1 x Peptide Cartridge Pen
* 1 x Pen Carry Case
* 3 x Pen Needle Tips

Single Mixed Cartridges (1,2 & 3) Come with:

* 1,2 or 3 x Cartridge (The cartridge is premixed with the peptide vial of your choice and Bacteriostatic Water)
* 3 x Pen Needle Tips
The single 1,2 & 3 cartridges do not come with a kit.

Buy 10 and get 10% Discount

499 in stock

Description

SS-31 Elamipretide Pre Mixed Peptide 25mg Pen United Kingdom

This product is intended for research purposes only. To be used by trained professionals only.

Elamipretide, also known as SS-31, is a synthetic tetrapeptide that has shown significant promise in biomedicine. It is part of a new family of drugs that selectively target mitochondria, the powerhouses of cells, in order to restore their function. This peptide can cross cell and organelle membranes and is hypothesised to interfere with the generation of reactive oxygen species within the mitochondria, resulting in enhanced physiological function [1].

SS-31 Elamipretide pre mixed peptide has been proven in recent United Kingdom research to alleviate mitochondrial dysfunction, synaptic damage, and memory loss in mice produced by lipopolysaccharides [2]. This highlights the peptide’s potential as a treatment for neurodegenerative disorders including Alzheimer’s and Parkinson’s, in which mitochondrial dysfunction is a prominent pathogenic hallmark.

SS-31’s interaction with membranes and effect on surface electrostatics is one of its primary chemical mechanisms of action [3]. It binds specifically to cardiolipin, a phospholipid found only on the inner mitochondrial membrane. Cardiolipin changes have been linked to ageing and a variety of disorders, implying that SS-31 elamipretide pre mixed peptide could have a wide range of therapeutic applications.

SS-31 has also been shown to influence BAX recruitment and activation during apoptosis [4], thereby reducing cell death and boosting cellular health. Furthermore, SS-31 Elamipretide pre mixed peptide has been shown to reduce age-related post-translational changes of heart proteins [5], suggesting its potential utility in the treatment of age-related cardiac disorders.

SS-31 elamipretide pre mixed peptide has also been demonstrated in United Kingdom clinical studies to improve ADP sensitivity in aged mitochondria by boosting uptake via the adenine nucleotide translocator [1]. This suggests that it has the potential to cure age-related energy decrease at the cellular level.


References:

[1] https://link.springer.com/ article/10.1007/s11357-023-00861-y

[2] https://link.springer.com/ article/10.1186/s12974-019-1627-9

[3] https://www.biorxiv.org/ content/10.1101/735001v1.abstract

[4] https://link.springer.com/ article/10.1186/s13104-021-05613-9

[5] https://link.springer.com/ article/10.1007/s11357-021-00447-6


Sequence: d-Arg-Dmt-Lys-Phe-NH2

Molecular Formula: C32H49N9O5

Molecular Weight: 639.8 g/mol

Storage: Lyophilized peptides stored below -18°C.

Research use only. Not for human or animal consumption!


DISCLAIMER: We do not supply peptides to any individual under the age of 21. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used ONLY in the process of laboratory research by responsible trained and professional individuals. All products listed on this website (https://united-kingdom.direct-peptides.com) and provided through Direct Peptides are intended for laboratory research purposes only. The products listed on this website are NOT for human or animal consumption or ingestion of any kind.


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