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LL-37 Nasal Spray

£45.84£86.68

Buy LL-37 (CAP-18) Nasal Spray

LL-37, also known as CAP-18, is a unique human peptide belonging to the cathelicidin family of antimicrobial peptides. It serves multiple functions in the human immune system, including the suppression of neutrophil apoptosis via the activation of formyl-peptide receptor-like 1, and the stimulation of host defences against microbes while reducing pro-inflammatory cytokine responses. LL-37 can affect various pathogens such as bacteria, viruses like HIV, fungi, and even those residing in biofilms, showcasing its broad-spectrum antimicrobial activity.

LL-37 15ml Contains 5mg
LL-37 30ml Contains 10mg

Buy 10 and get 10% Discount

468 in stock

Description

LL-37 Nasal Spray United Kingdom

This product is intended for research purposes only. To be used by trained professionals only.

LL-37, also known as CAP-18, is a human peptide belonging to the cathelicidin family of antimicrobial peptides. It plays multiple roles in the human immune system, modulating innate immune responses, and preventing bacterial biofilm formation [1].

This multifunctional peptide can be up-regulated during an immune response. Its capabilities include protecting mice against lethal endotoxemia [2], indicating its potential for therapeutic applications in infections and sepsis. Moreover, it has been observed to prevent the formation of bacterial biofilms, which are structured communities of bacteria that contribute to chronic infections [3].

LL-37’s immunomodulatory role has been studied in the context of autoimmune diseases and viral infections. It has been found that both CD4+ and CD8+ LL-37-reactive T cells exist in patients with moderate-to-severe plaque psoriasis, suggesting that LL-37 nasal spray may influence the activation of these immune cells [4].

In addition to its immunomodulatory functions, United Kingdom research has demonstrated that LL-37 nasal spray peptide has angiogenic properties, promoting the growth of new blood vessels, mediated by formyl peptide receptor-like 1 expressed on endothelial cells [5]. This finding opens up potential avenues for therapeutic use in wound healing and tissue regeneration.

The interaction of LL-37 nasal spray with lipid bilayers has also been explored. Despite being highly charged, LL-37 interacts variably with lipid bilayers depending on their composition, which could influence its antimicrobial activity [6].

Interestingly, United Kingdom studies have shown that the LL-37 peptide can inhibit HIV-1 replication, suggesting potential applications in antiviral therapy. Furthermore, the antibacterial activity of LL-37 has been found to be conformation-dependent, providing insights into the structural basis of its function [7].


References:

[1] https://journals.aai.org/jimmunol/ article/191/10/4895/86783

[2] https://journals.aai.org/jimmunol/ article/169/7/3883/35412

[3] https://journals.asm.org/doi/full/ 10.1128/iai.00318-08

[4] https://www.mdpi.com/ 2076-393X/8/3/517

[5] https://www.jci.org/articles/ view/17545

[6] https://pubs.acs.org/doi/abs/ 10.1021/bi0273563

[7] https://www.jbc.org/article/ S0021-9258(18)93785-3/fulltext


Sequence: Leu Leu Gly Asp-Phe-Phe Arg Lys-Ser Lys-Glu Lys.11e-Gly Lys Glu Phe Lys-Arg Ile Val-Gln Are Ile-Lys Asp Phe Leu Arg Asn Leu Val Pro-Arg Thr-Glu-Ser

Molecular Formula: C205 H340 N60 O53

Molecular Weight: 4493.342 g/mol

Storage: Lyophilized peptides to be stored below -18°C

Research use only. Not for human or animal consumption!

LL-37 HPLC 2023 Certificates_DIRECT PEPTIDES

 

 

 

 

 

 

 

 


DISCLAIMER: We do not supply peptides to Any individual under the age of 18. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used in the process of medical research by responsible trained and professional individuals. All products listed on this website (https://united-kingdom.direct-peptides.com) and provided through Direct Peptides are intended for medical research purposes only. Direct Peptides does not encourage or promote the use of any of these products in a personal capacity (i.e. human consumption), nor are the products intended to be used as a drug, stimulant or for use in any food products.


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