Buy ACE-031 Peptide United Kingdom
Ace-031 peptide, or ACVR2B, is a myostatin inhibitor that has been researched for its potential use in treating muscle wasting diseases. Myostatin is a protein that controls muscle cell growth and development, and blocking its function can lead to increased muscle mass and strength.
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ACE-031 Nasal Spray
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ACE-031 1mg Pre Mixed
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ACE-031
£96.42 – £105.40 This product has multiple variants. The options may be chosen on the product page
What is ACE-031?
ACE-031 is a soluble form of activin receptor type IIB, also known as ActRIIB-Fc. ACE-031 is often described as a “inhibiting myostatin.” This is due to its ability to inhibit myostatin, a protein that suppresses muscle growth.
This peptide that plays a crucial role in muscle growth and development. It is a synthetic form of a naturally occurring protein that acts as a myostatin blocker.
By blocking myostatin, it can lead to significant increases in muscle mass. This makes it a focus of medical research. In particular for conditions that cause severe muscle wasting such as Duchenne Muscular Dystrophy (DMD).
Furthermore, it may improve bone density and enhance physical performance by affecting bone metabolism. Research continues to better assess its effectiveness and safety, especially concerning potential side effects.
ACE-031 Mechanism Of Action
ACE-031 helps build muscle by blocking myostatin, a protein that normally limits muscle growth. Myostatin controls muscle size by reducing the number of new muscle fibers and managing the growth of existing ones. By interfering with myostatin, it promotes greater skeletal muscle growth. This process encourages muscle protein synthesis, leading to increased strength.
It not only supports muscle growth but also affects bone metabolism. It boosts bone mineral density and increases bone mass by targeting different pathways. These pathways are related to bone formation and resorption. This dual effect on both muscle and bone makes it a promising option. It could be beneficial for treating issues like severe muscle atrophy and osteoporosis.
It may enhance insulin sensitivity and improve oxidative respiration. These effects can lead to optimized energy use and increased endurance during physical activities. Research is ongoing to better understand its full effects and to assess any potential side effects from its use.
ACE-031 Research and Clinical Insights
- Recent United Kingdom studies show that ACE 031 may effectively target myostatin / activin A signaling. This can help treat diseases linked to muscle loss and metabolic issues. Its effectiveness comes from its ability to bind to several members of the TGF-β family, acting as a receptor antagonist [1].
- Clinical trials have shown that it increases muscle mass. This indicates it may be effective in treating conditions like cachexia and sarcopenia. The doses used in these studies ranged from 0.02 to 3 mg/kg, and subjects were randomized across six groups [2].
- Studies suggest it has shown promise as a treatment for muscular dystrophy [3]. It was awarded orphan status and accelerated review by the FDA for this indication in 2010 [4].
- Research indicates that ACE 031 is not just a selective inhibitor. It can also block BMP8, BMP9, and activins [5]. These findings help expand its potential application scope in muscle-related disorders.
- ACE031, a modified version of ACVR2B. It has been studied for its potential therapeutic advantages in addressing sarcopenia. This is a condition characterized by loss of muscle mass and strength associated with aging.[6]. However, its development was halted due to safety concerns.
- Postmenopausal women administered with ACE 031 showed an increase in lean body mass [7]. This United Kingdom research suggests potential uses for addressing issues related to decreased muscle mass in postmenopausal women.
- It significantly increased both type 1 and type 2 muscle fibers, according to a study [8]. This makes it a potential agent in enhancing overall muscle function and strength.
- ACE-2494, an upgraded version of ACE-031, has been developed. It has proven effective in promoting muscle mass and bone growth [9]. This indicates that treatments based on ACE-031 continue to evolve and improve.
- Research shows that muscle loss in cancer cells is connected to metabolic stress and higher levels of free radicals. Introducing ACE-031 activates the ERK1/2 pathway, which might prevent muscle atrophy. It also boosts energy efficiency and mitochondrial metabolism while reducing free radicals. Myostatin, often found in certain cancers, leads to reduced muscle mass, but exposure to ACE-031 could help reverse this effect. Additionally, blocking myostatin may improve insulin sensitivity, reduce fat storage, lower inflammation, and enhance bone metabolism and strength [10].
What Are The Benefits of ACE-031?
Increase in Muscle Mass: It works by blocking the myostatin protein, which usually limits muscle growth. This action lead to notable increases in muscle size and strength. This makes it useful for conditions like Duchenne Muscular Dystrophy (DMD) that cause severe muscle wasting [11].
Bone Density Improvement: It can enhance bone mineral density and increase bone mass by repairing and regenerating bone tissue. This dual action on both muscle and bone is beneficial for treating osteoporosis and improving overall physical performance.
Energy Use Optimization: It reduces blood glucose levels and enhances the process in which cells use oxygen to convert nutrients into ATP. These improvements lead to better energy use and greater endurance. This can enhance athletic performance and support overall physical activity.
Regulating Myostatin for Muscle Regeneration: Myostatin plays a key role in muscle growth and regeneration, particularly during exercise. The action of research product ACE-031 helps maintain and build muscle tissue more effectively.
Potential Use in Wound Healing: It may promote muscle development and support cell regeneration, which could be beneficial for wound healing and aid in the recovery of muscle tissues damaged by injury or surgery.
Support in Muscle Wasting Syndromes: United Kingdom Research indicates that it may help reduce the effects of muscle wasting syndromes. These are associated with lower myostatin levels and loss of muscle mass. This can support muscle health after surgery or in degenerative conditions.
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Buy ACE-031 Pre-Mixed Pen
Buy ACE-031 pre-mixed 1 mg pen from Direct Peptides is a simple solution for administering peptides in research. This innovative delivery system removes the need for complicated preparation or reconstitution. This allows researchers to focus on their studies with fewer distractions.
The pen provides accurate dosing and easy application, making it perfect for controlled experiments. The ACE 031 pre-mixed pen peptide is a valuable tool for studying muscle growth therapies.
Buy ACE-031 pre-mixed 1mg pen United Kingdom, available here in 1, 2, or 3 pre-mixed cartridges or as a kit. The kit includes a cartridge pen, carry case and needle tips.
Buy ACE-031 Peptide Nasal Spray
Buy ACE-031 nasal spray, a convenient and innovative method for exploring muscle growth peptides. The spray is designed to offer swift absorption into the bloodstream. This provides a faster onset of action compared to traditional methods.
The nasal spray is available in 15ml and 30ml bottles. This easy-to-use delivery system removes the need for injections. This makes it simpler for subjects to comply with the treatment. ACE 031 nasal spray proves to be a versatile and essential tool in peptide research.
Buy ACE-031 nasal spray United Kingdom from Direct Peptides. Available here in 15 ml and 30 ml glass spray bottles.
Frequently Asked Questions (FAQs) about ACE-031 Peptide
Is ACE-031 approved for clinical use?
Currently, it is not approved for general clinical use by the FDA. Whilst it showed promise in clinical trials for several muscle-related conditions, such as muscular dystrophy. Its development was stopped due to safety concerns.
ACE-031 is mainly available for research purposes and laboratory use, requiring more study and further development to resolve these safety issues and fully explore its therapeutic potential.
What are the possible side effects of ACE-031?
Possible side effects of ACE-031 may include side effects typical of other drugs affecting muscle growth, such as changes in blood sugar levels or energy metabolism. However, comprehensive safety profiles are still being studied.
It is important to note that use of these products are not meant for human consumption. They are strictly for research use.
Who can benefit from ACE-031?
United Kingdom Research suggests that conditions characterized by the loss of muscle or weakness, such as Duchenne Muscular Dystrophy and age-related sarcopenia, might benefit from ACE-031. However, its use is currently limited to research settings.
What is the future of ACE-031 in therapeutic treatments?
While it shows significant potential in muscle-related therapies, ongoing research and clinical trials are vital to fully understand its benefits and any associated risks. Future advancements like ACE-2494 demonstrate continued interest in developing safer, more effective treatments.
Can you stack ACE 031 with other peptides?
Early studies using mouse models suggest that effective muscle protection during wasting may require a comprehensive approach. This involves combining treatments that promote muscle growth, like growth hormone and IGF-1, with those that reduce the loss of muscle, such as ACE 031.
Buy ACE-031 Peptides United Kingdom +98% Pure from Direct Peptides.
Summary of Research Applications
- Blocks the activity of myostatin to enhance skeletal muscle development
- Potential treatment of DMD.
- Promotes performance by improving energy efficiency.
- Helps lower blood glucose levels.
- Strengthens bones by improving bone mineral density and increasing bone mass through its impact on bone metabolism.
- Has potential to help postmenopausal women by improving muscle strength and lean body mass.
ACE-031 Peptide Quality Assured
At Direct Peptides, we are dedicated to providing the highest quality ACE 031 peptides to research professionals. Our quality assurance processes ensure that each batch meets strict industry standards. We guarantee a purity of at least 98%. Therefore, researchers can trust that they are getting a reliable and effective product for their studies.
Choosing Direct Peptides means you can confidently buy ACE-031 peptide United Kingdom. Our peptides support advanced research in muscle growth and therapy. Our dedication to excellence makes us a trusted partner in the scientific community, driving significant advancements and innovative solutions.
References For Further Reading
[1] Se-Jin Lee, Shalender Bhasin, Lloyd Klickstein, Venkatesh Krishnan, and Daniel Rooks (2023) Challenges and Future Prospects of Targeting Myostatin/Activin A Signaling to Treat Diseases of Muscle Loss and Metabolic Dysfunction – The Journals of Gerontology: Series A, Volume 78 (Issue Supplement 1), June 2023, Pages 32–37.
[2] Thomas Kung, Jochen Springer, Wolfram Doehner, Stefan D Anker, and Stephan von Haehling (2009) Novel treatment approaches to cachexia and sarcopenia: highlights from the 5th Cachexia Conference – Expert Opinion on Investigational Drugs, Volume 19, 2010 – Issue 4.
[3] Masakazu Saitoh, Junichi Ishida, Nicole Ebner, Stefan D. Anker, et al (2017) Myostatin inhibitors as pharmacological treatment for muscle wasting and muscular dystrophy – JCSM Clinical Reports, Volume 2, Issue 1, January 2017, Pages 1-10.
[4] Rosamund C Smith and Boris K Lin (2013) Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders – Current Opinion In Supportive and Palliative Care. 2013 Nov 6, Volume 7 (Issue 4), Pages 352–360.
[5] Kathryn R Wagner (2020) The elusive promise of myostatin inhibition for muscular dystrophy – Current Opinion in Neurology, Volume 33 (Issue 5), Pages 621-628, October 2020.
[6] Ju Yeon Kwak and Ki-Sun Kwon (2019) Pharmacological Interventions for Treatment of Sarcopenia: Current Status of Drug Development for Sarcopenia – Annals of Geriatric Medicine and Research, 2019 Sep 23, Volume 23 (Issue 3), Pages 98–104.
[7] Eric Marty, Yi Liu, Andre Samuel, Omer Or, Joseph Lane (2017) A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease – Bone Journal, Volume 105, December 2017, Pages 276-286.
[8] Joonho Suh and Yun-Sil Lee (2020) Myostatin Inhibitors: Panacea or Predicament for Musculoskeletal Disorders? – Journal of Bone and Metabolism, 2020 Aug 31, Volume 27 (Issue 3), Pages 151–165.
[9] Yang Feike, Liu Zhijie, and Chen Wei (2021) Advances in research on pharmacotherapy of sarcopenia – Aging Medicine, Volume 4 (Issue 3) September 2021, Pages 221-233.
[10] H Q Han, Xiaolan Zhou, William E Mitch, and Alfred L Goldberg (2013) Myostatin/activin pathway antagonism: molecular basis and therapeutic potential – International Journal of Biochemistry and Cell Biology, 2013 Oct, Volume 45 (Issue 10), Pages 2333-47.
[11] Craig Campbell, Hugh J McMillan, Jean K Mah, Mark Tarnopolsky, Kathryn Selby, Ty McClure, et al (2016) Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial. Muscle Nerve, 2017 Apr, Volume 55 (Issue 4), Pages 458-464.
Why Choose Direct Peptides United Kingdom?
Direct Peptides is a leading option for researchers looking to buy ACE-031 peptide United Kingdom. Their product offering includes a variety of formulations to suit different research requirements. These include peptide vials and easy-to-use delivery methods such as nasal sprays and pre-mixed pens. All their peptides are guaranteed 99% pure or 98% for complex compounds. Their strict quality control processes guarantee reliable research results. This positions Direct Peptides as a reliable partner in scientific research.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our United Kingdom Direct Peptides website: https://united-kingdom.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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